The UHMWPE Lexicon is the online reference for ultra-high molecular weight polyethylene used in total joint replacements. The additional goals for this website are to provide an overview of state-of-the-art research in several key polyethylene related problems of clinical significance and to encourage hypothesis driven polyethylene research. [+] Read more about us.

Publications & Reports

Preliminary Program: 8th International UHMWPE Meeting, Oct. 19-20, 2017

The University of Torino, the Implant Research Center of Drexel University and Exponent, Inc., are pleased to provide the preliminary program for the 8th International UHMWPE Meeting. The meeting itself will be convened in Torino, Italy, on Thursday and Friday, October 19 and 20, 2017. The purpose of the meeting is to bring together engineers, scientists, and clinicians from academia and industry and present leading edge research on advancements in medical grade UHMWPE technology and clinical applications. Click here for more information about the preliminary program for the meeting.

Draft FDA Guidance for Characterization of UHMWPE

FDA has developed this draft guidance document for members of industry who submit and FDA staff who review testing of orthopedic devices using ultrahigh molecular weight polyethylene (UHMWPE) material. This guidance addresses the characterization and testing of orthopedic devices that use UHMWPE materials such as conventional UHMWPE, highly crosslinked UHMWPE, and highly crosslinked UHMWPE containing vitamin E. This document outlines the information that the FDA recommends should be included in a submission to FDA to characterize the UHMWPE material (e.g., material description, sterility, biocompatibility, mechanical properties, and chemical properties).

PhD Disseration: Biologic Response to Wear Debris in Total Disc Replacement

In this PhD Dissertation, Sai Veruva investigated both explants and periprosthetic tissue retrievals from patients with gamma-inert-sterilized TDRs to characterize in vivo performance and biological response, respectively. As pain was the primary revision reason for all patients, the contributions of implant-related damage and tissue responses to the development of pain were also a focus of this investigation.

The 3rd Edition of the UHMWPE Biomaterials Handbook

The 3rd Edition of the UHMWPE Biomaterials Handbook, edited by Steven M. Kurtz, Ph.D., is published by Elsevier Academic Press. Now with 41 chapters, the third edition includes six new chapters on a range of topics, including the latest in anti-oxidant technologies for stabilizing HXLPE and up-to-date systematic reviews of the clinical literature for HXLPE in hips and knees. The book chronicles the rise and fall of all-metal hip implants, as well as the increased use of ceramic biomaterials and UHMWPE for this application. This book also brings orthopedic researchers and practitioners up to date on the stabilization of UHMWPE with antioxidants, as well as the choices of antioxidant available for practitioners. The book can be ordered via the Amazon website or downloaded as an Ebook. A preview of the Ebook is also available.

Conferences Updates

Register Online for the 8th International UHMWPE Meeting in Torino, Italy

The Implant Research Center of Drexel University in collaboration with the University of Torino and Exponent is organizing the 8th International UHMWPE Meeting, which will be convened in Torino Italy, on October 19-20, 2017. The purpose of the meeting is to bring together engineers, scientists, and clinicians from academia and industry and present leading edge research on advancements in medical grade UHMWPE technology and clinical applications. Check back soon for a preliminary agenda. 


Principal Organizers: The meeting will be organized by Steve Kurtz (Drexel University/Exponent) and Pierangiola Bracco (University of Torino). 


Venue: The meeting (like last time in 2013) will be convened at the "Unione Industriale" located in central Torino, in walking distance of accomodations and the historic town center. Click here for a bucket list of things to do in the beautiful and historic city of Torino.


Registration: Early bird registration is $375 for professionals, $185 for government employees and students. These fees will expire on September 14. Standard registration is $475 for professionals and $215 for government employees and students. Click here to register online for the UHMWPE conference. 


Accomodations: Based on feedback from the last meeting, we have elected not to reserve a meeting block, because of the many hotels within walking distance of the Unione Industriale. As a first choice, please consider the Turin Palace Hotel (despite its fancy name it is an economical business traveler hotel located conveniently next to the main train station. It is also ranked the #1 hotel in Turin by Tripadvisor). We have also scouted the Golden Palace Hotel and the Hotel Victoria. These are also convenient to the conference venue. 


Social Program: The organizers believe that collaborations flourish not only in the formal structure of a meeting but more often in informal social gatherings. To that end, we have organized a gala dinner on evening of Thursday, October 19. The cost of the social program will be covered in the conference registration fee.


Sponsorship: We are pleased to announce that Celanese will be supporting the 8th International Meeting as a Platinum Sponsor. We also welcome the involvement of Lima Corporate, Orthoplastics, Quadrant Meditech and Stryker Orthopaedics as Bronze Sponsors.


Standards Updates

UHMWPE Standards at ASTM

The Working Group for UHMWPE convenes twice per year at the ASTM F04 Committee Week meetings in May and November. Check the ASTM Website for more details on the F04 Committee Week.